Anti Lysyl oxidasebuy
The anti-lysyl oxidase peptide is a critical tool in scientific research, primarily used to study and inhibit the activity of lysyl oxidase (LOX) enzymes. These enzymes play a vital role in the extracellular matrix, particularly in collagen and elastin cross-linking, which is essential for tissue structure and integrityAnti-Lysyl Oxidase antibody detects human Lysyl Oxidase. Lysyl Oxidase (LOX) belongs to a heterogeneous family of enzymes that oxidize primary amine .... Consequently, anti-LOX peptides and antibodies are valuable for investigating a range of biological processes and pathological conditions, including fibrosis, cancer, and tissue remodeling.
Lysyl oxidases are a family of copper-dependent amine oxidases that catalyze the oxidative deamination of specific lysine and hydroxylysine residues in collagen and elastin.Human Synthetic Lysyl Oxidase (LOX) Peptide This process is foundational for the formation of stable intermolecular cross-links, which confer mechanical strength and resilience to connective tissues. The LOX enzyme family includes LOX and several LOX-like proteins (LOXL1-LOXL4), each with distinct but related functions in tissue development, maintenance, and diseaseThe antibody is affinity- purified using the immunizingpeptideimmobilized on agarose.Anti-Lysyl Oxidasespecifically recognizes human lysyloxidase(LOX).. Research into these enzymes has revealed their involvement in processes as diverse as wound healing, arterial calcification, tumor suppression, and the progression of fibrotic diseases.Anti-Lysyl Oxidaseantibody produced in rabbit (Anti-LOX ); ~ 1mg/mL, affinity isolated antibody, buffered aqueous solution; Suitable for western blot; ...
Anti-lysyl oxidase peptides are often synthesized to mimic specific regions of the LOX protein, typically used as immunogens to generate antibodies or as blocking peptides to neutralize antibody binding.作者：T Li·2018—Anti-LOX inhibited LOX activity to reduce pyridinoline level, which led penile tunica albuginea remolding. Finally,anti-LOX had no impact on erectile function, ... This allows researchers to precisely target and study LOX activity.LOX Antibody Blocking Peptide (NB100-2530PEP) For instance, a LOX peptide can be used in conjunction with an anti-LOX antibody to confirm the specificity of antibody-based detection methods, such as Western blotting or immunohistochemistryAnti-Lysyl oxidase homolog 1 LOXL1 Antibody. By pre-incubating the antibody with its corresponding peptide, researchers can demonstrate that the antibody indeed binds to the intended target, thereby validating experimental results.
Furthermore, synthetic peptides derived from LOX can also serve as inhibitors or modulators of LOX enzyme activity. Studies have explored the use of anti-LOX antibodies and related peptides in therapeutic contextsAnti-lysyl oxidaselike 1 antibodies are used for the immunodetection of the protein encoded by the LOXL1 gene.. For example, research has investigated how anti-lysyl oxidase treatments, sometimes in combination with other devices, might influence tissue remodeling, such as in studies exploring penile lengtheningLOX Antibody Blocking Peptide (NB100-2530PEP). While this specific application is niche, it highlights the broader potential of targeting LOX activity to alter tissue properties.Anti-Lysyl oxidase Antibody Products
The primary utility of anti-LOX peptides and antibodies lies in their application in various research fields:
* Fibrosis Research: LOX enzymes are implicated in the excessive deposition of extracellular matrix proteins characteristic of fibrotic diseases affecting organs like the lungs, liver, and kidneysAnti-Lysyl oxidase Antibody Products. Anti-LOX agents are used to investigate the role of LOX in driving fibrosis and to explore potential therapeutic strategies to inhibit this process. For example, peptide-derived from endostatin has shown anti-fibrotic activity by reducing LOX expression.
* Cancer Biology: LOX and its family members have been linked to tumor progression, metastasis, and angiogenesis.Anti-Lysyl oxidaseantibodies are available from several suppliers. In humans, this protein is encoded by the gene LOX. The protein may also be known as Xlox, ... They can influence the tumor microenvironment, promote cell migration, and contribute to resistance to chemotherapy. Researchers use anti-LOX antibodies and peptides to study these mechanisms and to evaluate LOX inhibitors as potential anti-cancer agents作者：Y Zhao·2009·被引用次数：76—Thelysyl oxidase(LOX)2 gene family is comprised of five members LOX, LOXL1, LOXL2, LOXL3, and LOXL4, which encode enzymes that modify extracellular matrix ( .... Some studies investigate how inhibitors can "rewire" collagen architecture, enhancing chemotherapy response in triple-negative breast cancer.
* Tissue Engineering and Regenerative Medicine: The role of LOX in cross-linking extracellular matrix components makes it relevant to tissue engineering efforts aimed at creating functional biomaterials and tissues作者：T Takihara·2012—APeptideDerived From Endostatin ExhibitsAnti-fibrotic Activity By Reducing The Expression OfLysyl Oxidase(LOX) And Early Growth Response-1 (Egr-1).. Understanding how to modulate LOX activity could be crucial for controlling the mechanical properties and degradation rates of engineered tissues.
* Vascular Health: LOX is involved in the structural integrity of blood vessels. Lysyl oxidase deficiency has been identified as a cause of human arterial dissection, underscoring the enzyme's critical importance in vascular health. Research using anti-LOX tools helps elucidate these roles and potential therapeutic targets for vascular diseases.
When working with anti-lysyl oxidase peptides, it is essential to consider their source, purity, and intended application.作者：T Li·2020·被引用次数：11—This study aimed to explore whether and howanti-lysyl oxidase(anti-LOX) combined with a vacuum device (VD) could promote penile lengthening. Synthetic peptides are often preferred for their defined sequences and high purity. Researchers must also be aware of the different members of the LOX family, as antibodies and peptides may exhibit varying degrees of specificity towards LOX versus LOXL proteins.
The development of novel LOX inhibitors, including peptide-based ones, continues to be an active area of research. These agents hold promise for treating a spectrum of diseases characterized by aberrant extracellular matrix remodeling. As our understanding of the intricate roles of lysyl oxidases in health and disease deepens, the importance of tools like anti-lysyl oxidase peptide will undoubtedly grow, paving the way for new diagnostic and therapeutic interventionsLysyl oxidase.
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