VIPomapancreas Vasoactive intestinal peptide (VIP) is a crucial peptide hormone with significant roles in various bodily functions, including its notable presence and influence within the pancreasDefinition of vasoactive intestinal peptide - NCI Dictionary .... While VIP is produced in multiple tissues, its connection to the pancreas is particularly relevant in understanding certain physiological processes and pathological conditions. This peptide plays a key part in regulating pancreatic secretion and is associated with rare pancreatic neuroendocrine tumors known as VIPomas作者：S Ravindranathan·2022·被引用次数：36—Targeting vasoactive intestinal peptide-mediated signalingenhances response to immune checkpoint therapy in pancreatic ductal adenocarcinoma..
Vasoactive intestinal peptide exerts a considerable influence on both the endocrine and exocrine functions of the pancreas. In its exocrine capacity, VIP is believed to stimulate pancreatic fluid and bicarbonate secretion, contributing to digestion作者：S Jiang·1997·被引用次数：66—Vasoactive intestinal peptide (VIP) appears to be responsible for atropine-resistant, neurally mediated pancreatic ductal bicarbonate secretion.. Research has indicated that VIP may be responsible for neurally mediated pancreatic ductal bicarbonate secretion.Effects of vasoactive intestinal peptide and pancreatic ... Furthermore, it has been shown to influence the release of hormones from the endocrine pancreas, though its precise effects on glucagon secretion remain a subject of investigation作者：LI Larsson·1978·被引用次数：133—The vasoactive intestinal polypeptide (VIP) has been shown toexert effects on endocrine and exocrine pancreatic secretion.. Its presence has been detected in VIP-immunoreactive cells within the pancreas, particularly in the islets of Langerhans.Endocrine cells derived chemokine vasoactive intestinal polypeptide ...
A critical aspect of the relationship between VIP and the pancreas is the development of VIPomas. These are very rare pancreatic neuroendocrine tumors (PNETs) that arise most commonly from the islet cells of the pancreas.Vasoactive intestinal peptide The defining characteristic of a VIPoma is its excessive secretion of vasoactive intestinal peptideVIPoma causes cells in thepancreasto produce a high level of a hormone calledvasoactive intestinal peptide(VIP). This hormone increases secretions from the .... This overproduction of VIP leads to a distinct clinical syndrome, often referred to as Verner-Morrison syndrome or WDHA syndrome (watery diarrhea, hypokalemia, and achlorhydria)Vasoactive intestinal peptide reduces oxidative stress in ....
The surge in VIP levels associated with these tumors triggers a cascade of effects, including increased intestinal secretions, leading to profuse watery diarrhea.作者：E ADEGHATE·2000·被引用次数：7—1 Although, VIP has been shown to stimulate insulin release from normalpancreas,2 its role on glucagon secretion is still unclear. The aim of ... Other symptoms can include electrolyte imbalances like hypokalemia (low potassium levels) and gastric hypoacidity or achlorhydria (lack of stomach acid). While typically originating in the pancreas, VIP-secreting tumors can rarely occur elsewhere.
Diagnosing a VIPoma typically involves a combination of clinical suspicion, imaging studies, and laboratory tests.作者：LI Larsson·1978·被引用次数：133—The vasoactive intestinal polypeptide (VIP) has been shown toexert effects on endocrine and exocrine pancreatic secretion. The presence of severe watery diarrhea, especially when accompanied by electrolyte abnormalities, raises suspicion.A hormone found in the pancreas, intestine, and central nervous system. It has many actions in the body, such as helping to control the secretion of water, ... A VIP blood test can reveal elevated levels of the peptide. Imaging modalities such as CT scans or MRI are used to locate the tumor within the pancreas or surrounding areas.
The primary treatment for a VIPoma is surgical removal of the tumor, which can often lead to a complete cure if the tumor is localized and successfully resected. In cases where surgery is not feasible or the tumor has metastasized, medical management focuses on controlling the debilitating symptoms of diarrhea and electrolyte imbalances. Medications aimed at reducing VIP secretion or blocking its effects may be employed.作者：WW de Herder·2023·被引用次数：12—A VIPoma is a neuroendocrine neoplasm secretingvasoactive intestinal peptide(VIP), usually presenting with severe watery secretory diarrhea.
While VIPomas represent a significant clinical association, vasoactive intestinal peptide also has broader implications for pancreatic healthVasoactive intestinal peptide. Research suggests that VIP may play a role in protecting against pancreatic injury, such as experimental acute pancreatitis, by inhibiting the production of inflammatory cytokines. Its potential to modulate insulin release from the pancreas also highlights its complex involvement in glucose homeostasis.
In summary, vasoactive intestinal peptide is an integral component of pancreatic physiology, influencing secretion and cellular function. Its aberrant production by VIPomas underscores its potent biological activity and the critical need for understanding its role in rare but serious pancreatic conditions.
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