GE11 peptidesequence The GE11 peptide has emerged as a significant tool in the fight against cancer, particularly for tumors that overexpress the epidermal growth factor receptor (EGFR). This dodecapeptide, identified through phage display, exhibits a remarkable ability to specifically bind to EGFR with high affinity and selectivityStore at 2 to 4°C before hydration and at -70°C after rehydration. Most peptides are stable for approximately 3-6 month after rehydration. Typically, any .... Its primary application lies in its capacity to act as a targeting agent, enabling the precise delivery of therapeutic payloads, such as anticancer drugs and imaging agents, directly to cancer cells作者：X Li·2020·被引用次数：21—This study aimed to radiolabelGE11(an EGFR-specific targetingpeptide) with 18-fluorine to develop a new EGFR-targeting positron emission tomography (PET) .... This targeted approach holds immense promise for enhancing treatment efficacy while minimizing systemic side effects作者：M Hallaji·2025·被引用次数：7—This study focuses on an Fc-fusionpeptideconsisting of the Fc region of IgG1 and an epidermal growth factor receptor (EGFR)-targetingpeptide, GE11..
The development and application of GE11 peptide-based strategies have seen considerable research over the past decade. Its conjugation to various drug delivery systems, including liposomes, micelles, and nanoparticles, has been a key focusLabeling approaches for the GE11 peptide, an epidermal .... These modified systems are designed to selectively deliver loaded drugs into cancer cells that exhibit high EGFR expression, thereby enhancing therapeutic outcomes.作者：Z Guo·2022·被引用次数：21—We developed an epidermal growth factor receptor-targeted multifunctional micellar nanoplatform (GE11-DOX+CEL-M) by encapsulating celecoxib into polymeric ... For instance, GE11 peptide-conjugated liposomes have been developed to improve the therapeutic index of anticancer drugs by increasing their accumulation within tumor cells. Similarly, GE11-decorated acidity-responsive micelles can encapsulate drugs like celecoxib, further refining targeted delivery.
Beyond drug delivery, the GE11 peptide also plays a crucial role in cancer diagnostics and imaging.作者：B Judmann·2022·被引用次数：5—In conclusion, a monovalentGE11 peptideor a low number of GE11 peptide units per radiotracer molecule appears to be of limited utility to ... Its ability to bind to EGFR makes it an attractive candidate for developing radioligands for diagnostic imaging techniques like positron emission tomography (PET) and magnetic resonance imaging (MRI)作者：MA Yuanzheng·2020—In the past 15 years, more systematic and in-depth studies on theEGFR-targeted GE11 peptidehave been carried out in the prevention, diagnosis .... By labeling GE11 with radionuclides, researchers can create agents that visualize EGFR expression in tumors, aiding in early diagnosis and monitoring treatment response. GE11-CSO-SPION micelles, for example, can be utilized as MRI contrast agents to detect hepatocellular carcinoma (HCC) with high EGFR expression, offering reliable data for early diagnosis.
The efficacy of the GE11 peptide stems from its specific interaction with the epidermal growth factor receptor (EGFR). EGFR is a transmembrane protein that plays a critical role in cell growth and proliferation. In many types of cancer, EGFR is overexpressed or mutated, leading to uncontrolled cell division.作者：H Jiao·2020·被引用次数：16—TheEGFR-targeting peptide GE11was synthesized with the introduction of four amino acids (GGGC) to its C-terminal to act as a strong chelator and radiolabeled ... The GE11 peptide, with its amino acid sequence often cited as YHWYGYTPQNVI, functions as a ligand that binds to the extracellular domain of EGFR.作者：WW Xu·2017·被引用次数：45—In this study, dual therapeutic-loadedGE11 peptide-conjugated liposomeswere developed and applied to enhance therapeutic efficacies of standard-of-care ... This binding event is highly specific, meaning GE11 preferentially attaches to EGFR over other cellular receptors, a characteristic that underpins its utility in targeted therapies. Studies have demonstrated its binding affinity to EGFR, with dissociation constants (Kd) reported in the nanomolar range, indicating a strong and stable interaction. This high affinity is crucial for effective targeting and subsequent drug delivery or imaging.
The integration of GE11 peptide into various drug delivery platforms has significantly expanded its therapeutic potentialGE11 peptide-decorated acidity-responsive micelles for .... By conjugating GE11 to nanocarriers, researchers aim to leverage its EGFR-targeting capability to achieve precise drug localization within tumor sites.
* Liposomes: GE11 peptide-conjugated liposomes are a prominent example. These liposomes can encapsulate chemotherapeutic agents, and upon administration, the GE11 peptide guides them to EGFR-overexpressing cancer cellsEGFR-targeting peptide GE11is an epidermal growth factor receptor (EGFR)-specific ligand for active targeting of EGFR-overexpressing cancer cells, Conjugation .... This targeted delivery can lead to higher drug concentrations within the tumor, potentially increasing efficacy and reducing off-target toxicity. Research has explored dual therapeutic-loaded GE11 peptide-conjugated liposomes to amplify therapeutic effects.
* Nanoparticles: Various types of nanoparticles have been modified with GE11 peptide.作者：WW Xu·2017·被引用次数：45—In this study, dual therapeutic-loadedGE11 peptide-conjugated liposomeswere developed and applied to enhance therapeutic efficacies of standard-of-care ... These include reduction-responsive hyaluronic acid-based nanoparticles and PLGA/TPGS nanoparticlesSynthesis of a novel 99m Tc labeled GE11 peptide for .... These systems are engineered to release their therapeutic cargo under specific conditions within the tumor microenvironment, further enhancing targeted action. For instance, GE11-modified nanoparticles have shown higher efficacy in delivering doxorubicin for breast cancer treatment.
* Micelles: GE11 peptide-decorated micelles offer another avenue for targeted drug delivery. These systems can encapsulate hydrophobic drugs and are designed to respond to stimuli like tumor acidityGE11 Peptide Conjugated Liposomes for EGFR-Targeted .... This allows for controlled release of the drug at the tumor site after GE11-mediated targeting.
The GE11 peptide's specific affinity for EGFR also makes it a valuable tool for diagnostic applications, particularly in visualizing EGFR expression in tumors.
* Radiolabeling for PET and SPECT: GE11 peptide can be radiolabeled with isotopes such as Technetium-99m (99mTc) or Fluorine-18 (18F)作者：M Hallaji·2025·被引用次数：7—This study focuses on an Fc-fusionpeptideconsisting of the Fc region of IgG1 and an epidermal growth factor receptor (EGFR)-targetingpeptide, GE11.. These radiolabeled peptides can then be used as tracers in Positron Emission Tomography (PET) or Single-Photon Emission Computed Tomography (SPECT) scans. These imaging techniques allow for the quantification of EGFR expression in vivo, which can aid in patient selection for EGFR-targeted therapies and in monitoring treatment response. Studies have focused on optimizing labeling approaches to ensure the stability and targeting efficiency of these radiotracers.
* MRI Contrast Agents: GE11 peptide has also been incorporated into MRI contrast agents, such as GE11-CSO-SPION micelles. These agents can enhance the visibility of tumors with high EGFR expression in MRI scans, contributing to more accurate diagnosis and staging of cancers like HCC.
Despite the significant progress in GE11 peptide research, several challenges remain. One challenge is the potential for EGFR receptor activation by the GE11 peptide itself, which could complicate therapeutic outcomes. Additionally, the affinity of a single GE11 molecule for EGFR may sometimes be insufficient for optimal targeting, necessitating the use of multiple GE11 units per molecule or conjugate.Bispecific peptide conjugate and radioactive ... The stability and shelf-life of GE11 peptide, especially after rehydration, also require careful consideration for practical clinical applications. Storage conditions, typically at 2-4°C before hydration and -70°C after rehydration, are recommended to maintain peptide integrity for approximately 3-6 months.GE11 was identified as a potential EGFR-specific peptidein 2005 by phage display and was shown to bind with a K d of 22.3 ± 0.4 nM to the EGFR.
Future research is likely to focus on overcoming these challenges by developing more robust and efficient GE11-based delivery systems, exploring novel modifications to enhance binding affinity and reduce off-target effects, and further refining radiolabeling techniques for improved diagnostic imaging. The continued exploration of GE11 peptide's potential in combination therapies and its application against a broader spectrum of EGFR-expressing cancers will also be critical作者：Z Guo·2022·被引用次数：21—We developed an epidermal growth factor receptor-targeted multifunctional micellar nanoplatform (GE11-DOX+CEL-M) by encapsulating celecoxib into polymeric .... The development of bispecific peptide conjugates incorporating GE11 could also offer new therapeutic strategies. Ultimately, the GE11 peptide represents a vital component in the evolving landscape of precision oncology, offering targeted solutions for a range of challenging diseases.2023年2月11日—Most of the attempts were based on the leadGE11, as thispeptidewas previously described to be a highly potent EGFR-specific agent. However, ...
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