Vasoactive intestinal peptidetreatment Serum vasoactive intestinal peptide (VIP) plays a crucial role in human physiology, functioning both as a hormone and a neuropeptide. Its presence and levels in the blood are significant indicators for a variety of conditions, particularly in diagnosing rare tumors and understanding certain disease states.Plasma Vasoactive Intestinal Polypeptide Concentration ... Measuring serum VIP levels is a key diagnostic tool, especially when investigating symptoms like profuse diarrhea, and has emerged as a potential biomarker in conditions ranging from cardiovascular issues to inflammatory diseases.
Vasoactive intestinal peptide (VIP) itself is a 28-amino-acid peptide hormone primarily known for its potent vasodilator activity. It is synthesized and released by various cells, including neurons in the central and peripheral nervous systems, and endocrine cells in the gastrointestinal tract. While its name suggests a primary role in the intestines, VIP's influence extends to numerous other bodily functions, including regulating smooth muscle relaxation, modulating immune responses, and influencing neurotransmission. Its presence in serum provides a window into these systemic effects.
The primary clinical utility of measuring serum VIP levels lies in the diagnosis of specific medical conditions.Plasma Vasoactive Intestinal Polypeptide Concentration ... The most notable is the identification of vasoactive intestinal polypeptide-secreting tumors, commonly known as VIPomas. These very rare pancreatic neuroendocrine tumors (PNETs) are characterized by the excessive production and release of VIP, leading to a syndrome often marked by profuse watery diarrhea, hypokalemia, and gastric acid hypersecretion. Elevated serum VIP levels, often significantly higher than normal ranges, are a hallmark of VIPoma.2024年8月28日—Aid in diagnosis ofvasoactive intestinal polypeptidesecreting tumors (VIPomas). ||Collect in a prechilled tube. For instance, patients with VIPoma generally have elevated serum VIP levels ranging from 60 to as high as 2100 pg/mL, with levels greater than 200 pg/mL often considered indicative.
Beyond VIPomas, altered serum VIP levels have been implicated in various other health conditions. Research suggests that VIP-serum levels can be higher in patients with certain cardiovascular conditions, such as atrial fibrillation with left ventricular abnormalities, indicating its potential as a noninvasive biomarker for detecting specific cardiac issues. Furthermore, studies have explored the association of serum VIP with chronic obstructive pulmonary disease (COPD), noting that increased serum VIP levels can appear associated with acute exacerbations of the disease. In neurodegenerative conditions like Alzheimer's disease (AD), elevated serum VIP levels have also been observed when compared to healthy controls, suggesting a potential role in the disease's pathophysiology. Conversely, lower baseline VIP levels in certain patient populations, such as those with ankylosing spondylitis (AS), have been linked to worse disease outcomes, highlighting its prognostic value.
While diagnostic applications are significant, understanding VIP's inherent physiological functions provides context for its presence in serum. As a peptide hormone, VIP plays a key role in regulating smooth muscle relaxation, particularly in the gastrointestinal and respiratory tracts作者：W Wang·2019·被引用次数：12—Background: The neuropeptidevasoactive intestinal peptide(VIP) has been identified as inhibiting osteoclastogenesis and suppressing inflammation.. Its vasodilatory properties are crucial for maintaining blood flow and regulating blood pressure作者：N Natanzi·2009·被引用次数：7—Patients with VIPoma generally have elevatedserumVIP levels ranging from 60 to as high as 2100 pg/mL [7].Serumlevels greater than 200 pg/mL .... In the context of the intestines, VIP is involved in the secretion of water and electrolytes, contributing to digestive processesEndocrine cells derived chemokine vasoactive intestinal polypeptide ....
Moreover, VIP is recognized for its potent immunomodulatory properties.Vasoactive Intestinal Polypeptide (VIP) It can influence various immune cells and inflammatory pathways, acting as a mediator in both pro-inflammatory and anti-inflammatory responses depending on the context. Its role as a neuropeptide also means it participates in neurotransmission, affecting mood, stress responses, and cognitive functions.010397: Vasoactive Intestinal Polypeptide (VIP), Plasma Research into VIP gene polymorphisms, which are associated with its serum levels, further suggests a complex interplay between genetic factors and the peptide's systemic presence and impact on conditions like rheumatoid arthritis.
The measurement of serum vasoactive intestinal peptide is typically performed through a blood test.VIP plays a key role in regulating smooth muscle relaxation, secretion of water and electrolytes in the intestines, and modulation of immune responses. For accurate results, patient preparation is often required, which may include fasting for a specific period, usually 10-12 hours, prior to specimen collection. The blood sample is collected in a pre-chilled tube, and the serum or plasma is then analyzed for VIP concentration.
Interpreting VIP test results requires careful consideration of the patient's clinical presentation, symptoms, and other diagnostic findings. In healthy volunteers, a median VIP-serum level can range, for example, around 42.44 pg/mL, with a typical range from 12.9 to 98Vasoactive Intestinal Peptide Tumor - Natanzi - 2009.5 pg/mL. However, these reference ranges can vary slightly between laboratories. Significantly elevated levels, as seen in VIPoma cases, are generally above 200 pg/mL. Conversely, abnormally low levels might be relevant in other disease contexts, such as predicting poorer outcomes in certain inflammatory or autoimmune conditions.作者：M Hejna·2001·被引用次数：40—We have investigated theVIP-serum levels in patients with pancreatic cancer and colonic adenocarcinomaas compared to healthy controls.
In conclusion, serum vasoactive intestinal peptide is a multifaceted molecule with critical roles in both normal physiology and disease states. Its measurement serves as an invaluable diagnostic tool for rare endocrine tumors and offers potential as a biomarker for various systemic conditions, underscoring its importance in clinical diagnostics and ongoing medical research.
Join the newsletter to receive news, updates, new products and freebies in your inbox.