Elevated VIP no tumor Serum vasoactive intestinal peptide (VIP) concentration refers to the measurable amount of VIP, a peptide hormone, found in the blood. VIP plays a crucial role as a regulator of various physiological processes, including intestinal motility and fluid secretion, and is also recognized for its potent immunoregulatory properties. Deviations in serum VIP levels can indicate underlying medical conditions, most notably VIP-secreting tumors, known as VIPomas. Understanding normal ranges and factors influencing VIP concentration is essential for accurate diagnosis and management.作者：K Nishino·2025—The median serum VIP level in the entire cohort was287.7(interquartile range, 215.3–367.7) pg/mL (Table 1). Figure 1A through 1C illustrate ...
Vasoactive intestinal peptide, also known as vasoactive intestinal polypeptide, is a neuropeptide that functions as a hormoneSerum levels of vasoactive intestinal peptide (VIP) in .... It is synthesized and released by various cells throughout the body, including neurons, endocrine cells, and immune cellsPlasma Vasoactive Intestinal Polypeptide Concentration .... Its primary actions involve the gastrointestinal tract, where it promotes intestinal secretion and relaxation, contributing to nutrient absorption and waste elimination. Beyond the gut, VIP influences blood vessel dilation, cardiac function, and immune responses.
Determining serum VIP concentration typically involves a blood test. This is often performed when a VIPoma is suspected, a neuroendocrine tumor that inappropriately secretes large amounts of VIP. Elevated VIP levels are a hallmark of VIPomas and are strongly associated with severe secretory diarrhea, hypokalemia, and achlorhydria.
The interpretation of VIP levels is nuanced.Serum levels of vasoactive intestinal peptide (VIP) in ... Values obtained can be method-dependent, meaning different laboratory assay methods or kits may yield varying resultsPlasma vasoactive intestinal polypeptide concentration .... Therefore, it is critical for healthcare providers to consider the specific assay used when evaluating a patient's serum VIP concentrationVipoma - Endocrine and Metabolic Disorders.
Establishing a definitive "normal" range for serum VIP concentration can be challenging due to assay variability and physiological fluctuations.Plasma Vasoactive Intestinal Polypeptide Concentration ... However, studies provide reference points. For instance, in healthy controls, a median VIP-serum level has been reported around 42.44 ± 2VIP - Overview: Vasoactive Intestinal Polypeptide, Plasma.540 pg/mL, with a range of 12.9-98Rare Cases of Pediatric Vasoactive Intestinal Peptide ....5 pg/mL. Other studies have indicated mean serum concentrations in certain groups as low as 16 ± 8 pg/mL, with a range of 0-64 pg/mL.
In contrast, significantly elevated levels are indicative of pathology. Patients with VIPomas generally exhibit markedly increased serum VIP levels, often ranging from 60 to over 2100 pg/mL. A concentration consistently above 200 pg/mL is frequently considered diagnostic for a VIP-secreting tumor, particularly when accompanied by characteristic symptoms like debilitating diarrhea.Serum Vasoactive Intestinal Peptide as a Novel Biomarker ... For example, patients with VIPomas identified through diagnostic testing have shown plasma VIP concentrations exceeding 140 pg/mLVasoactive intestinal peptide test - VIP - UCSF Health.
VIPomas are rare tumors, most commonly found in the pancreas or duodenum. Their defining characteristic is the excessive production and release of VIP into the bloodstream作者：M Hejna·2001·被引用次数：40—Results: In healthy controls, amedian VIP-serum level of 42.44 +/- 2.540 pg/ml(range, 12.9-98.5 pg/ml) was found, while patients with pancreatic cancer had a .... This hormonal overload disrupts normal physiological functions, leading to a constellation of symptoms collectively known as Verner-Morrison syndrome or the VIPoma syndromePlasma Vasoactive Intestinal Polypeptide Concentration ....
The primary clinical manifestation of a VIPoma is profuse watery diarrhea, which can result in severe dehydration, electrolyte imbalances (especially hypokalemia), and metabolic acidosis. Other symptoms may include abdominal pain, nausea, vomiting, and flushing. In pediatric cases, laboratory abnormalities such as hypokalemia, achlorhydria, and acidosis have been noted alongside elevated plasma VIP.
Measuring serum VIP concentration is a vital diagnostic tool for identifying and managing VIPomas. The test is ideally performed during a bout of diarrhea to capture the most accurate reflection of the hormone's secretion. Elevated VIP levels, especially when coupled with the characteristic symptoms, strongly suggest the presence of a VIP-secreting tumor.
However, it's important to note that elevated VIP levels do not exclusively point to VIPomas. Other conditions, such as certain types of neuroendocrine tumors, ganglioneuroblastomas, and even some inflammatory conditions, can sometimes lead to increased VIP concentrations, although typically not to the extreme levels seen with VIPomas.VIPoma - StatPearls - NCBI Bookshelf - NIH The context of the patient's symptoms, medical history, and other laboratory findings are crucial for accurate interpretationDo Elevated Plasma Vasoactive Intestinal Polypeptide (VIP .... Furthermore, the possibility of "elevated VIP with no tumor" being detected in some cases highlights the complexity of VIP regulation and the need for comprehensive evaluation.
Serum vasoactive intestinal peptide (VIP) concentration is a critical biomarker for diagnosing and monitoring conditions associated with VIP dysregulation, most notably VIPomas. While normal ranges exist, significantly elevated levels, particularly those exceeding 200 pg/mL, are strongly suggestive of a VIP-secreting tumor. Understanding the method-dependent nature of VIP assays and considering the patient's clinical presentation are paramount for accurate interpretation. Continued research into VIP's multifaceted roles may further illuminate its significance in various physiological and pathological processesVasoactive Intestinal Peptide-Secreting Tumor (VIPoma).
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